PI单重态氧成像应用

单重态氧成像

分子氧是维持和熄灭生命以及破坏物质的最重要分子之一。几十年来，研究人员一直对分子氧的最低激发态单线态氧（1O2）的物理和化学性质感兴趣。单重态氧具有独特的反应性，可导致聚合物降解或生物细胞死亡。通过光动力疗法（PDT），可以利用其作为细胞死亡中间体的作用来治疗癌症，该技术利用光作为医学工具。

在PDT中，将光敏剂掺入异常组织中，然后用可见光照射，使其通过II型光化学途径将能量转移至基态氧，从而产生单重态氧（通过弱的1270 nm发射检测到）。已经提出了几种高空间分辨率的方法，以使用单个光电倍增管（PMT），线性InGaAs检测器阵列或二维InGaAs检测器来检测1O2发光。

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典型应用案例

Reactive oxygen species explicit dosimetry to predict tumor growth for BPD-mediated vascular photodynamic therapy

Photodynamic therapy (PDT) is a well-established treatment modality for cancer and other malignant diseases; however, quantities such as light fluence, photosensitizer photobleaching rate, and PDT dose do not fully account for all of the dynamic interactions between the key components involved. In particular, fluence rate (Φ) effects are not…

Tianqi Sheng
Proc. SPIE
2019

Singlet oxygen explicit dosimetry to predict long-term local tumor control for BPD-mediated photodynamic therapy

Photodynamic therapy (PDT) is a well-established treatment modality for cancer and other malignant diseases; however, quantities such as light fluence, photosensitizer photobleaching rate, and PDT dose do not fully account for all of the dynamic interactions between…

Michele M. Kim
Proc. SPIE
2017